MOLECULAR EVOLUTION
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MOLECULAR EVOLUTION
Kimura, M. (1968). Evolutionary rate at the molecular level. Nature, 217(5129), 624-626.
Molecular evolution is the subject of Kimura’s studies. Comparison of hemoglobin molecules from different animal species This suggests that, during the course of mammalian evolution, amino-acid substitution happened at a rate of roughly one amino-acid change per chain composed of some amino-acids. There must be a lot of neutral mutations in order for Kimura’s estimate of the rate at which evolution occurs to come out so high.’ It is possible to use neutral mutations as a form of “molecular clock” to describe genetic evolution since they act as a kind of “yardstick.” Kimura’s work is critical to this study because if the nearly neutral or neutral mutation is generated at a faster rate in each generation than previously thought, we ought to acknowledge the critical role of random genetic drift because to a restricted number of individuals in a group has an impact on the genetic makeup of that population.
King, J. L., & Jukes, T. H. (1969). Non-Darwinian Evolution: Most evolutionary change in proteins may be due to neutral mutations and genetic drift. Science, 164(3881), 788-798.
“Non-Darwinian Evolution” is a 1969 scientific study co-authored by Thomas H. Jukes and Jack Lester King. It is credited with suggesting what became recognized as “the neutral hypothesis of molecular evolution,” along with Motoo Kimura’s 1968 publication “Evolutionary Rate at the Molecular Level.” The study marshals a wealth of information, spanning from protein sequence analyses to investigations of the Treffer’s mutator genes in E. coli, genetic code analysis, and comparative immunology, to suggest that the majority of protein evolution occurs as a result of genetic drift and neutral mutations. The paper “non-Darwinian evolution” is relevant for my study since it offers an in-depth explanation of the concept of the neutral theory of molecular evolution
